Oxalosuccinic acid
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| Oxalosuccinic acid | |
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1-Oxopropane-1,2,3-tricarboxylic acid |
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| Identifiers | |
| CAS number | 1948-82-9  |
| PubChem | 972 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C6H6O7 |
| Molar mass | 190.11 g mol−1 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Oxalosuccinic acid is a substrate of the citric acid cycle. It is acted upon by isocitrate dehydrogenase. Salts and esters of oxalosuccinic acid are known as oxalosuccinates.
Oxalosuccinic acid/Oxalosuccinate is an unstable 6-Carbon intermediate in the TriCarboxylic Acid Cycle. It's an alpha-keto compound, formed during the oxidative decarboxylation of isocitrate to Alpha-Ketoglutarate, which is catalyzed by the enzyme Isocitrate Dehydrogenase. Oxalosuccinate never leaves the active site of the enzyme, however it's unstable and immediately undergoes decarboxylation to produce the 5-carbon compound, Alpha-Ketoglutarate.
| Citric Acid Cycle Metabolic Pathway | ||||||||||||||||||
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| Oxaloacetate | Malate | Fumarate | Succinate | Succinyl-CoA | ||||||||||||||
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| Acetyl-CoA | NADH + H+ | NAD+ | H2O | FADH2 | FAD | CoA + ATP(GTP) | Pi + ADP(GDP) | |||||||||||
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+ | H2O |  |
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NADH + H+ + CO2 | |||||||||||||
| CoA | NAD+ | |||||||||||||||||
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H2O |  |
H2O |  |
NAD(P)+ | NAD(P)H + H+ |  |
CO2 |  |
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| Citrate | cis-Aconitate | Isocitrate | Oxalosuccinate | α-Ketoglutarate | ||||||||||||||
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