By extension, the derivatives are also referred to as oxazines; examples include ifosfamide and morpholine (tetrahydro-1,4-oxazine). A commercially available dihydro-1,3-oxazine is a reagent in the Meyers synthesis for aldehydes. Fluorescent dyes such as Nile red and Nile blue are based on the aromatic benzophenoxazine.
Benzoxazine is a molecule where an oxazine ring is attached to a benzene ring. There are several benzoxazine structures depending on the position of the heteroatoms. The numbering is made in such a way that the oxygen position precedes the nitrogen. Thus, structure c is a 1,4-benzoxazine. This is because the benzoxazine was originally the compound with a double bond, such as in structured. The word, dihydro, indicates the hydrogenated version of benzoxazine. It is the 1,3-benzoxazines that are the subject of interest for development of polymeric materials as this class of benzoxazines readily polymerizes via cationic ring-opening polymerization. The IUPAC name avoids the reversing of 1,3 into 3,1 from the structure a into. Instead, the position of the oxygen is indicated by [e] for structure and [d] for structure b by alphabetically counting the atoms in the oxazine ring. While the accurate naming must still follow IUPAC notation, it is very complex and impractical for routine use. Thus, a convention has been developed to abbreviate the name of the benzoxazine.
- Oxazines at the US National Library of Medicine Medical Subject Headings (MeSH)
- Development of polymeric materials as a class of benzoxazines