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Oxo may refer to:
- OXO, the first digital graphical computer game, a version of Tic-tac-toe from 1951
- Oxo (food), a brand of food products in the UK, South Africa and Canada
- OXO Tower, a London landmark formerly owned by the makers of Oxo food products
- OXO (brand), a US-based manufacturer of ergonomic handheld kitchen utensils
- Oxo ligand, a divalent ligand
- oxo-, a prefix in the formal IUPAC nomenclature for the functional group '=O' (a substituent oxygen atom connected to another atom by a double bond)
- Oxo synthesis, another name for hydroformylation
- OXO (band), an 80s New Wave pop band
- Oxo (horse), a racehorse, winner of the 1959 Grand National
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