Oxoeicosanoid receptor 1

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Oxoeicosanoid (OXE) receptor 1
Identifiers
Symbols OXER1 ; GPCR; GPR170; TG1019
External IDs HomoloGene65034 IUPHAR: OXE ChEMBL: 1628461 GeneCards: OXER1 Gene
Orthologs
Species Human Mouse
Entrez 165140 n/a
Ensembl ENSG00000162881 n/a
UniProt Q8TDS5 n/a
RefSeq (mRNA) NM_148962 n/a
RefSeq (protein) NP_683765 n/a
Location (UCSC) Chr 2:
42.99 – 42.99 Mb
n/a
PubMed search [1] n/a

Oxoeicosanoid receptor 1 (i.e., OXER1) is a protein that in humans is encoded by the OXER1 gene.[1][2][3]

Function[edit]

OXER1 is a G protein-coupled receptor that couples to and activates the Gαi/o subclass of G proteins; OXER1 binds and is thereby activated by i.e. 5(S)-HETE and 5-oxo-ETE, as well as other members of this family of arachidonic acid metabolites.[4][5][1][6][7][8]

OXER1 closely resembles in the hydroxy-carboxylic acid nature of its binding ligands as well as in its amino acid sequence to a subfamily of G protein-coupled receptor, the hydroxy-caboxlic acid receptors, which include GPR109A, PPR109B, GPR81, and possibly the orphan receptor GPR31.[9][10]

The function and role of OXER1 is covered in 5-Hydroxyicosatetraenoic acid and 5-oxo-eicosatetraenoic acid.

See also[edit]


References[edit]

  1. ^ a b Hosoi T, Koguchi Y, Sugikawa E, Chikada A, Ogawa K, Tsuda N, Suto N, Tsunoda S, Taniguchi T, Ohnuki T (Aug 2002). "Identification of a novel human eicosanoid receptor coupled to G(i/o)". J Biol Chem 277 (35): 31459–65. doi:10.1074/jbc.M203194200. PMID 12065583. 
  2. ^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (Mar 2004). "International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor". Pharmacol Rev 56 (1): 149–57. doi:10.1124/pr.56.1.4. PMID 15001665. 
  3. ^ "Entrez Gene: OXER1 oxoeicosanoid (OXE) receptor 1". 
  4. ^ O'Flaherty JT, Rossi AG (1993). "5-hydroxyicosatetraenoate stimulates neutrophils by a stereospecific, G protein-linked mechanism". J. Biol. Chem. 268 (20): 14708–14. PMID 8392058. 
  5. ^ O'Flaherty JT, Taylor JS, Thomas MJ (1998). "Receptors for the 5-oxo class of eicosanoids in neutrophils". J. Biol. Chem. 273 (49): 32535–41. doi:10.1074/jbc.273.49.32535. PMID 9829988. 
  6. ^ Jones CE, Holden S, Tenaillon L, Bhatia U, Seuwen K, Tranter P, Turner J, Kettle R, Bouhelal R, Charlton S, Nirmala NR, Jarai G, Finan P (2003). "Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils". Mol. Pharmacol. 63 (3): 471–7. doi:10.1124/mol.63.3.471. PMID 12606753. 
  7. ^ Hosoi T, Sugikawa E, Chikada A, Koguchi Y, Ohnuki T (2005). "TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis". Biochem. Biophys. Res. Commun. 334 (4): 987–95. doi:10.1016/j.bbrc.2005.06.191. PMID 16039985. 
  8. ^ Bäck M, Powell WS, Dahlén SE, Drazen JM, Evans JF, Serhan CN, Shimizu T, Yokomizo T, Rovati GE (2014). "Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7". Br. J. Pharmacol. 171 (15): 3551–74. doi:10.1111/bph.12665. PMID 24588652. 
  9. ^ Ahmed K, Tunaru S, Offermanns S (2009). "GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors". Trends Pharmacol. Sci. 30 (11): 557–62. doi:10.1016/j.tips.2009.09.001. PMID 19837462. 
  10. ^ Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (2011). "International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)". Pharmacol. Rev. 63 (2): 269–90. doi:10.1124/pr.110.003301. PMID 21454438. 

Further reading[edit]

  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
  • Jones CE, Holden S, Tenaillon L, Bhatia U, Seuwen K, Tranter P, Turner J, Kettle R, Bouhelal R, Charlton S, Nirmala NR, Jarai G, Finan P (2003). "Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils". Mol. Pharmacol. 63 (3): 471–7. doi:10.1124/mol.63.3.471. PMID 12606753. 
  • Sundaram S, Ghosh J (2006). "Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival". Biochem. Biophys. Res. Commun. 339 (1): 93–8. doi:10.1016/j.bbrc.2005.10.189. PMID 16289380. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.