p14ARF is an alternate reading frame (ARF) product of the CDKN2A locus. Both p16INK4a and p14ARF are involved in cell cycle regulation. p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the G1/S checkpoint of the cell cycle. Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in mdm2 and, therefore, loss of p53 function and cell cycle control.
The equivalent in mice is p19ARF.
Clinical Significance [edit]
Homozygous deletions and other mutations of CDK2NA (ARF) have been found to be associated with glioblastoma.[1]
See also [edit]
References [edit]
- ^ Cancer Genome Atlas Research, Network (2008 Oct 23). "Comprehensive genomic characterization defines human glioblastoma genes and core pathways.". Nature 455 (7216): 1061–8. PMID 18772890.
External links [edit]
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| Cyclin |
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| CDK |
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| CDK inhibitor |
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| P53 p63 p73 family |
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Phases and
checkpoints |
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B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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