P2RX1

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Purinergic receptor P2X, ligand-gated ion channel, 1
Identifiers
Symbols P2RX1 ; P2X1
External IDs OMIM600845 MGI1098235 HomoloGene1921 IUPHAR: P2X1 ChEMBL: 2094 GeneCards: P2RX1 Gene
RNA expression pattern
PBB GE P2RX1 210401 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5023 18436
Ensembl ENSG00000108405 ENSMUSG00000020787
UniProt P51575 P51576
RefSeq (mRNA) NM_002558 NM_008771
RefSeq (protein) NP_002549 NP_032797
Location (UCSC) Chr 17:
3.8 – 3.82 Mb
Chr 11:
73 – 73.02 Mb
PubMed search [1] [2]

P2X purinoceptor 1 is a protein that in humans is encoded by the P2RX1 gene.[1]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.[2]

See also[edit]

References[edit]

  1. ^ Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (Nov 1996). "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder". Receptors Channels 3 (4): 283–9. PMID 8834001. 
  2. ^ "Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1". 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.