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Purinergic receptor P2X, ligand-gated ion channel, 2
Symbols P2RX2 ; DFNA41; P2X2
External IDs OMIM600844 MGI2665170 HomoloGene14251 IUPHAR: 479 ChEMBL: 2531 GeneCards: P2RX2 Gene
RNA expression pattern
PBB GE P2RX2 221372 s at tn.png
PBB GE P2RX2 221356 x at tn.png
More reference expression data
Species Human Mouse
Entrez 22953 231602
Ensembl ENSG00000187848 ENSMUSG00000029503
UniProt Q9UBL9 Q8K3P1
RefSeq (mRNA) NM_001282164 NM_001164833
RefSeq (protein) NP_001269093 NP_001158305
Location (UCSC) Chr 12:
133.2 – 133.2 Mb
Chr 5:
110.34 – 110.34 Mb
PubMed search [1] [2]

P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene.[1][2][3]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.[3]

See also[edit]


  1. ^ Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF (Dec 1999). "Molecular and functional characterization of human P2X(2) receptors". Mol Pharmacol 56 (6): 1171–81. PMID 10570044. 
  2. ^ Brake AJ, Wagenbach MJ, Julius D (Oct 1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor". Nature 371 (6497): 519–23. doi:10.1038/371519a0. PMID 7523952. 
  3. ^ a b "Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.