The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
^Garcia-Guzman M, Stuhmer W, Soto F (Sep 1997). "Molecular characterization and pharmacological properties of the human P2X3 purinoceptor". Brain Res Mol Brain Res47 (1–2): 59–66. doi:10.1016/S0169-328X(97)00036-3. PMID9221902.
Lewis C, Neidhart S, Holy C et al. (1995). "Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons". Nature377 (6548): 432–5. doi:10.1038/377432a0. PMID7566120.
Garcia-Guzman M, Soto F, Gomez-Hernandez JM et al. (1997). "Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue". Mol. Pharmacol.51 (1): 109–18. PMID9016352.
Renton T, Yiangou Y, Baecker PA et al. (2003). "Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp". Journal of orofacial pain17 (3): 245–50. PMID14520770.
Mason HS, Bourke S, Kemp PJ (2005). "Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species". Mol. Pharmacol.66 (6): 1525–35. doi:10.1124/mol.104.000851. PMID15331767.
Fabbretti E, Sokolova E, Masten L et al. (2005). "Identification of negative residues in the P2X3 ATP receptor ectodomain as structural determinants for desensitization and the Ca2+-sensing modulatory sites". J. Biol. Chem.279 (51): 53109–15. doi:10.1074/jbc.M409772200. PMID15475563.