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Purinergic receptor P2X, ligand-gated ion channel, 6
Symbols P2RX6 ; P2RXL1; P2X6; P2XM
External IDs OMIM608077 MGI1337113 HomoloGene3975 IUPHAR: P2X6 ChEMBL: 2670 GeneCards: P2RX6 Gene
RNA expression pattern
PBB GE P2RXL1 206880 at tn.png
PBB GE P2RXL1 211147 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9127 18440
Ensembl ENSG00000099957 ENSMUSG00000022758
UniProt O15547 O54803
RefSeq (mRNA) NM_001159554 NM_001159561
RefSeq (protein) NP_001153026 NP_001153033
Location (UCSC) Chr 22:
21.36 – 21.38 Mb
Chr 16:
17.56 – 17.58 Mb
PubMed search [1] [2]

P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.[1][2][3][4]

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[4]

See also[edit]


  1. ^ Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T (Sep 1997). "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res 57 (15): 3281–7. PMID 9242461. 
  2. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  3. ^ Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G (Sep 1996). "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci 16 (8): 2495–507. PMID 8786426. 
  4. ^ a b "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.