P2RY1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Purinergic receptor P2Y, G-protein coupled, 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols P2RY1 ; P2Y1
External IDs OMIM601167 MGI105049 HomoloGene1926 IUPHAR: P2Y1 ChEMBL: 4315 GeneCards: P2RY1 Gene
RNA expression pattern
PBB GE P2RY1 207455 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5028 18441
Ensembl ENSG00000169860 ENSMUSG00000027765
UniProt P47900 P49650
RefSeq (mRNA) NM_002563 NM_008772
RefSeq (protein) NP_002554 NP_032798
Location (UCSC) Chr 3:
152.55 – 152.56 Mb
Chr 3:
61 – 61.01 Mb
PubMed search [1] [2]

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[1]

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]

See also[edit]

References[edit]

  1. ^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (Mar 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochem Biophys Res Commun 218 (3): 783–788. doi:10.1006/bbrc.1996.0139. PMID 8579591. 
  2. ^ "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1". 

External links[edit]

  • "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.