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Purinergic receptor P2Y, G-protein coupled, 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols P2RY1 ; P2Y1
External IDs OMIM601167 MGI105049 HomoloGene1926 IUPHAR: 323 ChEMBL: 4315 GeneCards: P2RY1 Gene
RNA expression pattern
PBB GE P2RY1 207455 at tn.png
More reference expression data
Species Human Mouse
Entrez 5028 18441
Ensembl ENSG00000169860 ENSMUSG00000027765
UniProt P47900 P49650
RefSeq (mRNA) NM_002563 NM_001282016
RefSeq (protein) NP_002554 NP_001268945
Location (UCSC) Chr 3:
152.55 – 152.56 Mb
Chr 3:
61 – 61.01 Mb
PubMed search [1] [2]

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.[1]

The product of this gene, P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[2]

See also[edit]


  1. ^ Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (Mar 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor". Biochem Biophys Res Commun 218 (3): 783–788. doi:10.1006/bbrc.1996.0139. PMID 8579591. 
  2. ^ "Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1". 

External links[edit]

  • "P2Y Receptors: P2Y1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.