P2RY8
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| Purinergic receptor P2Y, G-protein coupled, 8 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | P2RY8; P2Y8 | ||||||||||||
| External IDs | OMIM: 300525 HomoloGene: 65345 IUPHAR: P2RY8 GeneCards: P2RY8 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 286530 | n/a | |||||||||||
| Ensembl | ENSG00000182162 | n/a | |||||||||||
| UniProt | Q86VZ1 | n/a | |||||||||||
| RefSeq (mRNA) | NM_178129.4 | n/a | |||||||||||
| RefSeq (protein) | NP_835230.1 | n/a | |||||||||||
| Location (UCSC) | Chr X: 1.58 – 1.66 Mb |
n/a | |||||||||||
| PubMed search | [1] | n/a | |||||||||||
P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.[1][2]
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.[2]
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[edit] Clinical relevance
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[3]
[edit] See also
[edit] References
- ^ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Sep 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim Biophys Acta 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
- ^ a b "Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=286530.
- ^ Lohr, JG; Stojanov, P, Lawrence, MS, Auclair, D, Chapuy, B, Sougnez, C, Cruz-Gordillo, P, Knoechel, B, Asmann, YW, Slager, SL, Novak, AJ, Dogan, A, Ansell, SM, Link, BK, Zou, L, Gould, J, Saksena, G, Stransky, N, Rangel-Escareño, C, Fernandez-Lopez, JC, Hidalgo-Miranda, A, Melendez-Zajgla, J, Hernández-Lemus, E, Schwarz-Cruz Y Celis, A, Imaz-Rosshandler, I, Ojesina, AI, Jung, J, Pedamallu, CS, Lander, ES, Habermann, TM, Cerhan, JR, Shipp, MA, Getz, G, Golub, TR (2012 Feb 17). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.". Proceedings of the National Academy of Sciences of the United States of America. PMID 22343534.
[edit] Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Cantagrel V, Lossi AM, Boulanger S, et al. (2005). "Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males.". J. Med. Genet. 41 (10): 736–42. doi:10.1136/jmg.2004.021626. PMC 1735597. PMID 15466006. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1735597.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286.
- Fujiwara S, Yamashita Y, Choi YL, et al. (2007). "Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening.". Leuk. Lymphoma 48 (5): 978–86. doi:10.1080/10428190701225882. PMID 17487742.
- Storlazzi CT, Albano F, Lo Cunsolo C, et al. (2007). "Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma.". Leukemia 21 (10): 2221–5. doi:10.1038/sj.leu.2404784. PMID 17554380.
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