PACRG

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PARK2 co-regulated
Identifiers
Symbols PACRG ; GLUP; HAK005771; PARK2CRG
External IDs OMIM608427 MGI1916560 HomoloGene16212 GeneCards: PACRG Gene
Orthologs
Species Human Mouse
Entrez 135138 69310
Ensembl ENSG00000112530 ENSMUSG00000037196
UniProt Q96M98 Q9DAK2
RefSeq (mRNA) NM_001080378 NM_027032
RefSeq (protein) NP_001073847 NP_081308
Location (UCSC) Chr 6:
163.15 – 163.74 Mb
Chr 17:
10.4 – 10.84 Mb
PubMed search [1] [2]

Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.[1][2]

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

References[edit]

  1. ^ West AB, Lockhart PJ, O'Farell C, Farrer MJ (Jan 2003). "Identification of a novel gene linked to parkin via a bi-directional promoter". J Mol Biol 326 (1): 11–9. doi:10.1016/S0022-2836(02)01376-1. PMID 12547187. 
  2. ^ a b "Entrez Gene: PACRG PARK2 co-regulated". 

Further reading[edit]