PAFAH2
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| Platelet-activating factor acetylhydrolase 2, 40kDa | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PAFAH2; HSD-PLA2 | ||||||||||||
| External IDs | OMIM: 602344 MGI: 2140321 HomoloGene: 37309 GeneCards: PAFAH2 Gene | ||||||||||||
| EC number | 3.1.1.47 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5051 | 100163 | |||||||||||
| Ensembl | ENSG00000158006 | ENSMUSG00000037366 | |||||||||||
| UniProt | Q99487 | Q8VDG7 | |||||||||||
| RefSeq (mRNA) | NM_000437.3 | NM_133880.2 | |||||||||||
| RefSeq (protein) | NP_000428.2 | NP_598641.2 | |||||||||||
| Location (UCSC) | Chr 1: 26.29 – 26.32 Mb |
Chr 4: 133.95 – 133.98 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene.[1][2][3]
This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme.[3]
[edit] References
- ^ Hattori K, Adachi H, Matsuzawa A, Yamamoto K, Tsujimoto M, Aoki J, Hattori M, Arai H, Inoue K (Jan 1997). "cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase". J Biol Chem 271 (51): 33032–8. doi:10.1074/jbc.271.51.33032. PMID 8955149.
- ^ Rice SQ, Southan C, Boyd HF, Terrett JA, MacPhee CH, Moores K, Gloger IS, Tew DG (May 1998). "Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor". Biochem J 330 (3): 1309–15. PMC 1219277. PMID 9494101. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1219277.
- ^ a b "Entrez Gene: PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5051.
[edit] Further reading
- Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM (1997). "Platelet-activating factor acetylhydrolases.". J. Biol. Chem. 272 (29): 17895–8. doi:10.1074/jbc.272.29.17895. PMID 9218411.
- Umemura K, Kato I, Hirashima Y, et al. (2007). "Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia.". Stroke 38 (3): 1063–8. doi:10.1161/01.STR.0000257981.09329.d2. PMID 17272759.
- Schmidt EB, Koenig W, Khuseyinova N, Christensen JH (2008). "Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids.". Atherosclerosis 196 (1): 420–4. doi:10.1016/j.atherosclerosis.2006.11.027. PMID 17157859.
- Unno N, Sakaguchi T, Nakamura T, et al. (2006). "A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease.". J. Surg. Res. 134 (1): 36–43. doi:10.1016/j.jss.2006.02.058. PMID 16650870.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Marques M, Pei Y, Southall MD, et al. (2002). "Identification of platelet-activating factor acetylhydrolase II in human skin.". J. Invest. Dermatol. 119 (4): 913–9. doi:10.1046/j.1523-1747.2002.01859.x. PMID 12406338.
- Min JH, Wilder C, Aoki J, et al. (2001). "Platelet-activating factor acetylhydrolases: broad substrate specificity and lipoprotein binding does not modulate the catalytic properties of the plasma enzyme.". Biochemistry 40 (15): 4539–49. doi:10.1021/bi002600g. PMID 11294621.
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