PAK2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
P21 protein (Cdc42/Rac)-activated kinase 2
Protein PAK2 PDB 1e0a.png
PDB rendering based on 1e0a.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PAK2 ; PAK65; PAKgamma
External IDs OMIM605022 MGI1339984 HomoloGene99711 ChEMBL: 4487 GeneCards: PAK2 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE PAK2 208875 s at tn.png
PBB GE PAK2 208876 s at tn.png
PBB GE PAK2 208877 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5062 224105
Ensembl ENSG00000180370 ENSMUSG00000022781
UniProt Q13177 Q8CIN4
RefSeq (mRNA) NM_002577 NM_177326
RefSeq (protein) NP_002568 NP_796300
Location (UCSC) Chr 3:
196.47 – 196.56 Mb
Chr 16:
32.02 – 32.08 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene.[1][2]

Function[edit]

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.[3]

Interactions[edit]

PAK2 has been shown to interact with:

References[edit]

  1. ^ Martin GA, Bollag G, McCormick F, Abo A (June 1995). "A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20". EMBO J 14 (9): 1970–8. PMC 398296. PMID 7744004. 
  2. ^ Knaus UG, Morris S, Dong HJ, Chernoff J, Bokoch GM (August 1995). "Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors". Science 269 (5221): 221–3. doi:10.1126/science.7618083. PMID 7618083. 
  3. ^ "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2". 
  4. ^ Roig J, Tuazon PT, Zipfel PA, Pendergast AM, Traugh JA (December 2000). "Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14346–51. doi:10.1073/pnas.97.26.14346. PMC 18921. PMID 11121037. 
  5. ^ Stevens WK, Vranken W, Goudreau N, Xiang H, Xu P, Ni F (May 1999). "Conformation of a Cdc42/Rac interactive binding peptide in complex with Cdc42 and analysis of the binding interface". Biochemistry 38 (19): 5968–75. doi:10.1021/bi990426u. PMID 10320322. 
  6. ^ Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A (November 1998). "PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia". EMBO J. 17 (22): 6527–40. doi:10.1093/emboj/17.22.6527. PMC 1171000. PMID 9822598. 
  7. ^ Zhang B, Chernoff J, Zheng Y (April 1998). "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA". J. Biol. Chem. 273 (15): 8776–82. doi:10.1074/jbc.273.15.8776. PMID 9535855. 
  8. ^ Kurakin AV, Wu S, Bredesen DE (September 2003). "Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening". J. Biol. Chem. 278 (36): 34102–9. doi:10.1074/jbc.M305264200. PMID 12829691. 

Further reading[edit]

External links[edit]