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P21 protein (Cdc42/Rac)-activated kinase 3
Protein PAK3 PDB 1e0a.png
PDB rendering based on 1e0a.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PAK3 ; CDKN1A; MRX30; MRX47; OPHN3; PAK3beta; bPAK; hPAK3
External IDs OMIM300142 MGI1339656 HomoloGene55664 IUPHAR: 2135 ChEMBL: 2999 GeneCards: PAK3 Gene
EC number
RNA expression pattern
PBB GE PAK3 214607 at tn.png
More reference expression data
Species Human Mouse
Entrez 5063 18481
Ensembl ENSG00000077264 ENSMUSG00000031284
UniProt O75914 Q61036
RefSeq (mRNA) NM_001128166 NM_001195046
RefSeq (protein) NP_001121638 NP_001181975
Location (UCSC) Chr X:
110.19 – 110.47 Mb
Chr X:
143.52 – 143.8 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase PAK 3 is an enzyme that in humans is encoded by the PAK3 gene.[1][2][3]


PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity.[3]

Clinical significance[edit]

A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation.[3]


PAK3 has been shown to interact with RAC1.[4]


  1. ^ Donnelly AJ, Partington MW, Ryan AK, Mulley JC (Nov 1996). "Regional localisation of two non-specific X-linked mental retardation genes (MRX30 and MRX31)". Am J Med Genet 64 (1): 113–20. doi:10.1002/(SICI)1096-8628(19960712)64:1<113::AID-AJMG19>3.0.CO;2-Q. PMID 8826460. 
  2. ^ Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA (Oct 1998). "PAK3 mutation in nonsyndromic X-linked mental retardation". Nat Genet 20 (1): 25–30. doi:10.1038/1675. PMID 9731525. 
  3. ^ a b c "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3". 
  4. ^ Shin OH, Exton JH (Aug 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794. 

Further reading[edit]

External links[edit]