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Par-3 family cell polarity regulator
Protein PARD3 PDB 2KOM.png
Rendering based on PDB 2KOM.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PARD3 ; ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A; PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2
External IDs OMIM606745 MGI2135608 HomoloGene10489 GeneCards: PARD3 Gene
RNA expression pattern
PBB GE PARD3 210094 s at tn.png
PBB GE PARD3 221526 x at tn.png
PBB GE PARD3 221280 s at tn.png
More reference expression data
Species Human Mouse
Entrez 56288 93742
Ensembl ENSG00000148498 ENSMUSG00000025812
UniProt Q8TEW0 Q99NH2
RefSeq (mRNA) NM_001184785 NM_001013580
RefSeq (protein) NP_001171714 NP_001013598
Location (UCSC) Chr 10:
34.4 – 35.1 Mb
Chr 8:
127.06 – 127.61 Mb
PubMed search [1] [2]

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.[1][2]

PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM][2]


PARD3 has been shown to interact with JAM3,[3] JAM2,[3] PVRL3[4] and PRKCI.[5]


  1. ^ Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. 
  2. ^ a b "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)". 
  3. ^ a b Ebnet, Klaus; Aurrand-Lions Michel, Kuhn Annegret, Kiefer Friedemann, Butz Stefan, Zander Kerstin, Meyer zu Brickwedde Maria-Katharina, Suzuki Atsushi, Imhof Beat A, Vestweber Dietmar (Oct 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell. Sci. (England) 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. ISSN 0021-9533. PMID 12953056. 
  4. ^ Takekuni, Kyoji; Ikeda Wataru; Fujito Tsutomu; Morimoto Koji; Takeuchi Masakazu; Monden Morito; Takai Yoshimi (Feb 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. (United States) 278 (8): 5497–500. doi:10.1074/jbc.C200707200. ISSN 0021-9258. PMID 12515806. 
  5. ^ Kohjima, Motoyuki; Noda Yukiko; Takeya Ryu; Saito Naoaki; Takeuchi Kosei; Sumimoto Hideki (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. (United States) 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. ISSN 0006-291X. PMID 12459187. 

Further reading[edit]