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Par-6 family cell polarity regulator alpha
Protein PARD6A PDB 1wmh.png
PDB rendering based on 1wmh.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PARD6A ; PAR-6A; PAR6; PAR6C; PAR6alpha; TAX40; TIP-40
External IDs OMIM607484 MGI1927223 HomoloGene9661 GeneCards: PARD6A Gene
RNA expression pattern
PBB GE PARD6A 205245 at tn.png
More reference expression data
Species Human Mouse
Entrez 50855 56513
Ensembl ENSG00000102981 ENSMUSG00000005699
UniProt Q9NPB6 Q9Z101
RefSeq (mRNA) NM_001037281 NM_001047435
RefSeq (protein) NP_001032358 NP_001040900
Location (UCSC) Chr 16:
67.69 – 67.7 Mb
Chr 8:
105.7 – 105.7 Mb
PubMed search [1] [2]

Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.[1][2][3]

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]


PARD6A has been shown to interact with CDC42,[2][4][5] RAC1,[2][5] ECT2[6] and Protein kinase Mζ.[2][6][7]


  1. ^ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (March 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110. 
  2. ^ a b c d Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. 
  3. ^ a b "Entrez Gene: PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans)". 
  4. ^ Joberty, G; Petersen C; Gao L; Macara I G (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. (ENGLAND) 2 (8): 531–9. doi:10.1038/35019573. ISSN 1465-7392. PMID 10934474. 
  5. ^ a b Qiu, R G; Abo A; Steven Martin G (June 2000). "A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation". Curr. Biol. (ENGLAND) 10 (12): 697–707. doi:10.1016/S0960-9822(00)00535-2. ISSN 0960-9822. PMID 10873802. 
  6. ^ a b Liu, Xiu-Fen; Ishida Hiroshi; Raziuddin Razi; Miki Toru (August 2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. (United States) 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. ISSN 0270-7306. PMC 444862. PMID 15254234. 
  7. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]