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Par-6 family cell polarity regulator alpha
Protein PARD6A PDB 1wmh.png
PDB rendering based on 1wmh.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PARD6A ; PAR-6A; PAR6; PAR6C; PAR6alpha; TAX40; TIP-40
External IDs OMIM607484 MGI1927223 HomoloGene9661 GeneCards: PARD6A Gene
RNA expression pattern
PBB GE PARD6A 205245 at tn.png
More reference expression data
Species Human Mouse
Entrez 50855 56513
Ensembl ENSG00000102981 ENSMUSG00000005699
UniProt Q9NPB6 Q9Z101
RefSeq (mRNA) NM_001037281 NM_001047435
RefSeq (protein) NP_001032358 NP_001040900
Location (UCSC) Chr 16:
67.69 – 67.7 Mb
Chr 8:
105.7 – 105.7 Mb
PubMed search [1] [2]

Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.[1][2][3]


This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]


PARD6A has been shown to interact with:


  1. ^ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (March 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110. 
  2. ^ a b c d Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. 
  3. ^ a b "Entrez Gene: PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans)". 
  4. ^ Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. 
  5. ^ a b Qiu RG, Abo A, Steven Martin G (June 2000). "A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation". Curr. Biol. 10 (12): 697–707. doi:10.1016/s0960-9822(00)00535-2. PMID 10873802. 
  6. ^ a b Liu XF, Ishida H, Raziuddin R, Miki T (August 2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMC 444862. PMID 15254234. 
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]