PARD6A

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Par-6 family cell polarity regulator alpha
Protein PARD6A PDB 1wmh.png
PDB rendering based on 1wmh.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PARD6A ; PAR-6A; PAR6; PAR6C; PAR6alpha; TAX40; TIP-40
External IDs OMIM607484 MGI1927223 HomoloGene9661 GeneCards: PARD6A Gene
RNA expression pattern
PBB GE PARD6A 205245 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 50855 56513
Ensembl ENSG00000102981 ENSMUSG00000005699
UniProt Q9NPB6 Q9Z101
RefSeq (mRNA) NM_001037281 NM_001047435
RefSeq (protein) NP_001032358 NP_001040900
Location (UCSC) Chr 16:
67.69 – 67.7 Mb
Chr 8:
105.7 – 105.7 Mb
PubMed search [1] [2]

Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.[1][2][3]

Function[edit]

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

Interactions[edit]

PARD6A has been shown to interact with:

References[edit]

  1. ^ Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P (March 1998). "The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins". Oncogene 16 (5): 643–54. doi:10.1038/sj.onc.1201567. PMID 9482110. 
  2. ^ a b c d Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. 
  3. ^ a b "Entrez Gene: PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans)". 
  4. ^ Joberty G, Petersen C, Gao L, Macara IG (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. 
  5. ^ a b Qiu RG, Abo A, Steven Martin G (June 2000). "A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation". Curr. Biol. 10 (12): 697–707. doi:10.1016/s0960-9822(00)00535-2. PMID 10873802. 
  6. ^ a b Liu XF, Ishida H, Raziuddin R, Miki T (August 2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMC 444862. PMID 15254234. 
  7. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 


Further reading[edit]