PARD6B

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Par-6 partitioning defective 6 homolog beta (C. elegans)
Protein PARD6B PDB 1nf3.png
PDB rendering based on 1nf3.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PARD6B ; PAR6B
External IDs OMIM608975 MGI2135605 HomoloGene23302 GeneCards: PARD6B Gene
RNA expression pattern
PBB GE PARD6B 211907 s at tn.png
PBB GE PARD6B 214827 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 84612 58220
Ensembl ENSG00000124171 ENSMUSG00000044641
UniProt Q9BYG5 Q9JK83
RefSeq (mRNA) NM_032521 NM_021409
RefSeq (protein) NP_115910 NP_067384
Location (UCSC) Chr 20:
49.35 – 49.37 Mb
Chr 2:
168.08 – 168.1 Mb
PubMed search [1] [2]

Partitioning defective 6 homolog beta is a protein that in humans is encoded by the PARD6B gene.[1][2]

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.[2]

Interactions[edit]

PARD6B has been shown to interact with CDC42,[1][3][4] RHOQ,[3][4] RAC1[1] and Protein kinase Mζ.[1]

References[edit]

  1. ^ a b c d Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (March 2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C". Genes Cells 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. 
  2. ^ a b "Entrez Gene: PARD6B par-6 partitioning defective 6 homolog beta (C. elegans)". 
  3. ^ a b Neudauer, C L; Joberty G, Macara I G (January 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem. Biophys. Res. Commun. (United States) 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. ISSN 0006-291X. PMID 11162552. 
  4. ^ a b Joberty, G; Petersen C, Gao L, Macara I G (August 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat. Cell Biol. (ENGLAND) 2 (8): 531–9. doi:10.1038/35019573. ISSN 1465-7392. PMID 10934474. 

Further reading[edit]