PARK7

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Parkinson protein 7
Protein PARK7 PDB 1j42.png
PDB rendering based on 1j42 [1].
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PARK7 ; DJ-1; DJ1
External IDs OMIM602533 MGI2135637 HomoloGene38295 GeneCards: PARK7 Gene
RNA expression pattern
PBB GE PARK7 200007 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11315 57320
Ensembl ENSG00000116288 ENSMUSG00000028964
UniProt Q99497 Q99LX0
RefSeq (mRNA) NM_001123377 NM_020569
RefSeq (protein) NP_001116849 NP_065594
Location (UCSC) Chr 1:
8.01 – 8.05 Mb
Chr 4:
150.9 – 150.91 Mb
PubMed search [1] [2]

Parkinson disease (autosomal recessive, early onset) 7, also known as PARK7, is a protein which in humans is encoded by the PARK7 gene.[2] It is also known as DJ-1.

Function[edit]

PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death.[2]

Clinical significance[edit]

Defects in this gene are the cause of autosomal recessive early-onset Parkinson's disease 7.[2][3]

Interactions[edit]

PARK7 has been shown to interact with EFCAB6[4] and Protein inhibitor of activated STAT2.[5]

See also[edit]

References[edit]

  1. ^ Lee, S. J.; Kim, S. J.; Kim, I. K.; Ko, J.; Jeong, C. S.; Kim, G. H.; Park, C.; Kang, S. O.; Suh, P. G. (2003). "Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved Domain". Journal of Biological Chemistry 278 (45): 44552–44559. doi:10.1074/jbc.M304517200. PMID 12939276.  edit
  2. ^ a b c "Entrez Gene: PARK7". 
  3. ^ Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P. (January 2003). "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism". Science 299 (5604): 256–259. doi:10.1126/science.1077209. PMID 12446870. 
  4. ^ Niki, Takeshi; Takahashi-Niki Kazuko, Taira Takahiro, Iguchi-Ariga Sanae M M, Ariga Hiroyoshi (Feb 2003). "DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex". Mol. Cancer Res. (United States) 1 (4): 247–61. ISSN 1541-7786. PMID 12612053. 
  5. ^ Takahashi, K; Taira T, Niki T, Seino C, Iguchi-Ariga S M, Ariga H (Oct 2001). "DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor". J. Biol. Chem. (United States) 276 (40): 37556–63. doi:10.1074/jbc.M101730200. ISSN 0021-9258. PMID 11477070. 

Further reading[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.