PATZ1

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POZ (BTB) and AT hook containing zinc finger 1
Protein PATZ1 PDB 2EPP.png
Rendering based on PDB 2EPP.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PATZ1 ; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG; dJ400N23
External IDs OMIM605165 MGI1891832 HomoloGene8636 GeneCards: PATZ1 Gene
RNA expression pattern
PBB GE PATZ1 209494 s at tn.png
PBB GE PATZ1 211392 s at tn.png
PBB GE PATZ1 209431 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23598 56218
Ensembl ENSG00000100105 ENSMUSG00000020453
UniProt Q9HBE1 Q5NBZ1
RefSeq (mRNA) NM_014323 NM_001253690
RefSeq (protein) NP_055138 NP_001240619
Location (UCSC) Chr 22:
31.72 – 31.74 Mb
Chr 11:
3.29 – 3.31 Mb
PubMed search [1] [2]

POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.[1][2][3][4]

Function[edit]

The protein encoded by this gene contains an AT-hook DNA binding motif, which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.[4]

Interactions[edit]

PATZ1 has been shown to interact with:

References[edit]

  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE et al. (December 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  2. ^ Fedele M, Franco R, Salvatore G, Paronetto MP, Barbagallo F, Pero R et al. (April 2008). "PATZ1 gene has a critical role in the spermatogenesis and testicular tumours". J Pathol 215 (1): 39–47. doi:10.1002/path.2323. PMID 18241078. 
  3. ^ Tian X, Sun D, Zhang Y, Zhao S, Xiong H, Fang J (April 2008). "Zinc finger protein 278, a potential oncogene in human colorectal cancer". Acta Biochim Biophys Sin (Shanghai) 40 (4): 289–96. doi:10.1111/j.1745-7270.2008.00405.x. PMID 18401526. 
  4. ^ a b "Entrez Gene: PATZ1 POZ (BTB) and AT hook containing zinc finger 1". 
  5. ^ a b Pero R, Lembo F, Palmieri EA, Vitiello C, Fedele M, Fusco A et al. (February 2002). "PATZ attenuates the RNF4-mediated enhancement of androgen receptor-dependent transcription". J. Biol. Chem. 277 (5): 3280–5. doi:10.1074/jbc.M109491200. PMID 11719514. 
  6. ^ Morii E, Oboki K, Kataoka TR, Igarashi K, Kitamura Y (March 2002). "Interaction and cooperation of mi transcription factor (MITF) and myc-associated zinc-finger protein-related factor (MAZR) for transcription of mouse mast cell protease 6 gene". J. Biol. Chem. 277 (10): 8566–71. doi:10.1074/jbc.M110392200. PMID 11751862. 
  7. ^ Fedele M, Benvenuto G, Pero R, Majello B, Battista S, Lembo F et al. (March 2000). "A novel member of the BTB/POZ family, PATZ, associates with the RNF4 RING finger protein and acts as a transcriptional repressor". J. Biol. Chem. 275 (11): 7894–901. doi:10.1074/jbc.275.11.7894. PMID 10713105. 

Further reading[edit]