PBX1

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Pre-B-cell leukemia homeobox 1
HoxB1-Pbx1 heterodimer binding DNA 1b72.png
Cartoon diagram of a HOXB1–PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PBX1 ; DKFZp686B09108; MGC126627
External IDs OMIM176310 MGI97495 HomoloGene20574 ChEMBL: 4587 GeneCards: PBX1 Gene
RNA expression pattern
PBB GE PBX1 205253 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5087 18514
Ensembl ENSG00000185630 ENSMUSG00000052534
UniProt P40424 P41778
RefSeq (mRNA) NM_001204961 NM_008783
RefSeq (protein) NP_001191890 NP_032809
Location (UCSC) Chr 1:
164.52 – 164.87 Mb
Chr 1:
168.15 – 168.43 Mb
PubMed search [1] [2]

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.[1]


Interactions[edit]

PBX1 has been shown to interact with HOXB1,[2][3] MEIS1[4][5][6] and HOXB7.[7]

References[edit]

  1. ^ "Entrez Gene: PBX1 Pre-B-cell leukemia homeobox 1". 
  2. ^ Berthelsen, J; Zappavigna V; Ferretti E; Mavilio F; Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. (ENGLAND) 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. ISSN 0261-4189. PMC 1170491. PMID 9482740. 
  3. ^ Piper, D E; Batchelor A H; Chang C P; Cleary M L; Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell (UNITED STATES) 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. ISSN 0092-8674. PMID 10052460. 
  4. ^ Shen, W F; Rozenfeld S; Kwong A; Köm ves L G; Lawrence H J; Largman C (Apr 1999). "HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell. Biol. (UNITED STATES) 19 (4): 3051–61. ISSN 0270-7306. PMC 84099. PMID 10082572. 
  5. ^ Shanmugam, K; Green N C; Rambaldi I; Saragovi H U; Featherstone M S (Nov 1999). "PBX and MEIS as Non-DNA-Binding Partners in Trimeric Complexes with HOX Proteins". Mol. Cell. Biol. (UNITED STATES) 19 (11): 7577–88. ISSN 0270-7306. PMC 84774. PMID 10523646. 
  6. ^ Jacobs, Y; Schnabel C A; Cleary M L (Jul 1999). "Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity". Mol. Cell. Biol. (UNITED STATES) 19 (7): 5134–42. ISSN 0270-7306. PMC 84356. PMID 10373562. 
  7. ^ Chang, C P; Shen W F; Rozenfeld S; Lawrence H J; Largman C; Cleary M L (Mar 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. (UNITED STATES) 9 (6): 663–74. doi:10.1101/gad.9.6.663. ISSN 0890-9369. PMID 7729685. 

Further reading[edit]

External links[edit]