PCBP1

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Poly(rC) binding protein 1
Protein PCBP1 PDB 1wvn.png
PDB rendering based on 1wvn.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PCBP1 ; HEL-S-85; HNRPE1; HNRPX; hnRNP-E1; hnRNP-X
External IDs OMIM601209 MGI1345635 HomoloGene68506 GeneCards: PCBP1 Gene
RNA expression pattern
PBB GE PCBP1 208620 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5093 23983
Ensembl ENSG00000169564 ENSMUSG00000051695
UniProt Q15365 P60335
RefSeq (mRNA) NM_006196 NM_011865
RefSeq (protein) NP_006187 NP_035995
Location (UCSC) Chr 2:
70.31 – 70.32 Mb
Chr 6:
86.52 – 86.53 Mb
PubMed search [1] [2]

Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.[1]

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.[2]

References[edit]

  1. ^ Tommerup N, Leffers H (May 1997). "Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A". Genomics 32 (2): 297–8. doi:10.1006/geno.1996.0121. PMID 8833161. 
  2. ^ "Entrez Gene: PCBP1 poly(rC) binding protein 1". 

Further reading[edit]