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Poly(rC) binding protein 1
Protein PCBP1 PDB 1wvn.png
PDB rendering based on 1wvn.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PCBP1 ; HEL-S-85; HNRPE1; HNRPX; hnRNP-E1; hnRNP-X
External IDs OMIM601209 MGI1345635 HomoloGene68506 GeneCards: PCBP1 Gene
RNA expression pattern
PBB GE PCBP1 208620 at tn.png
More reference expression data
Species Human Mouse
Entrez 5093 23983
Ensembl ENSG00000169564 ENSMUSG00000051695
UniProt Q15365 P60335
RefSeq (mRNA) NM_006196 NM_011865
RefSeq (protein) NP_006187 NP_035995
Location (UCSC) Chr 2:
70.31 – 70.32 Mb
Chr 6:
86.52 – 86.53 Mb
PubMed search [1] [2]

Poly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.[1]

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.[2]


  1. ^ Tommerup N, Leffers H (May 1997). "Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A". Genomics 32 (2): 297–8. doi:10.1006/geno.1996.0121. PMID 8833161. 
  2. ^ "Entrez Gene: PCBP1 poly(rC) binding protein 1". 

Further reading[edit]