PCBP2

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Poly(rC) binding protein 2
Protein PCBP2 PDB 1ztg.png
PDB rendering based on 1ztg.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PCBP2 ; HNRPE2; hnRNP-E2
External IDs OMIM601210 MGI108202 HomoloGene74536 GeneCards: PCBP2 Gene
RNA expression pattern
PBB GE PCBP2 204031 s at tn.png
PBB GE PCBP2 213263 s at tn.png
PBB GE PCBP2 213264 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5094 18521
Ensembl ENSG00000197111 ENSMUSG00000056851
UniProt Q15366 Q61990
RefSeq (mRNA) NM_001098620 NM_001103165
RefSeq (protein) NP_001092090 NP_001096635
Location (UCSC) Chr 12:
53.84 – 53.87 Mb
Chr 15:
102.47 – 102.5 Mb
PubMed search [1] [2]

Poly(rC)-binding protein 2 is a protein that in humans is encoded by the PCBP2 gene.[1]

The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.[2]

In humans, the PCBP2 gene overlaps with TUC338, a transcribed ultra-conserved element implicated in Hepatocellular carcinoma.[3]

Interactions[edit]

PCBP2 has been shown to interact with HNRPK,[4] PTBP1[4] and HNRNPL.[4]

References[edit]

  1. ^ Tommerup N, Leffers H (May 1997). "Assignment of human KH-box-containing genes by in situ hybridization: HNRNPK maps to 9q21.32-q21.33, PCBP1 to 2p12-p13, and PCBP2 to 12q13.12-q13.13, distal to FRA12A". Genomics 32 (2): 297–8. doi:10.1006/geno.1996.0121. PMID 8833161. 
  2. ^ "Entrez Gene: PCBP2 poly(rC) binding protein 2". 
  3. ^ Braconi, C; Valeri, N, Kogure, T, Gasparini, P, Huang, N, Nuovo, GJ, Terracciano, L, Croce, CM, Patel, T (2011-01-11). "Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma.". Proceedings of the National Academy of Sciences of the United States of America 108 (2): 786–91. doi:10.1073/pnas.1011098108. PMC 3021052. PMID 21187392. Retrieved 17 August 2011. 
  4. ^ a b c Kim, J H; Hahm B, Kim Y K, Choi M, Jang S K (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol. (ENGLAND) 298 (3): 395–405. doi:10.1006/jmbi.2000.3687. ISSN 0022-2836. PMID 10772858. 

Further reading[edit]