PCCG-4

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PCCG-4
PCCG-4 structure.png
Systematic (IUPAC) name
(2S,1'S,2'S,3'R)-2-(2'Carboxy-3'-phenylcyclopropyl)glycine
Clinical data
Legal status ?
Identifiers
ATC code ?
PubChem CID 5311344
ChemSpider 4470843 YesY
ChEMBL CHEMBL39573 YesY
Chemical data
Formula C12H13NO4 
Mol. mass 235.235 g/mol
 YesY (what is this?)  (verify)

PCCG-4 is a research drug which acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), with slight selectivity for mGluR2 although not sufficient to distinguish mGluR2 and mGluR3 responses from each other. It is used in research into the function of the group II metabotropic glutamate receptors.[1][2][3][4][5]

References[edit]

  1. ^ Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C (May 1996). "Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist". Journal of Medicinal Chemistry 39 (11): 2259–69. doi:10.1021/jm960059+. PMID 8667369. 
  2. ^ Thomsen C, Bruno V, Nicoletti F, Marinozzi M, Pellicciari R (July 1996). "(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors". Molecular Pharmacology 50 (1): 6–9. PMID 8700119. 
  3. ^ Cozzi A, Attucci S, Peruginelli F, Marinozzi M, Luneia R, Pellicciari R, Moroni F (July 1997). "Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist". The European Journal of Neuroscience 9 (7): 1350–5. doi:10.1111/j.1460-9568.1997.tb01489.x. PMID 9240392. 
  4. ^ Ciccarelli R, Di Iorio P, Bruno V, Battaglia G, D'Alimonte I, D'Onofrio M, Nicoletti F, Caciagli F (September 1999). "Activation of A(1) adenosine or mGlu3 metabotropic glutamate receptors enhances the release of nerve growth factor and S-100beta protein from cultured astrocytes". Glia 27 (3): 275–81. doi:10.1002/(SICI)1098-1136(199909)27:3<275::AID-GLIA9>3.0.CO;2-0. PMID 10457374. 
  5. ^ Vetter P, Garthwaite J, Batchelor AM (June 1999). "Regulation of synaptic transmission in the mossy fibre-granule cell pathway of rat cerebellum by metabotropic glutamate receptors". Neuropharmacology 38 (6): 805–15. doi:10.1016/S0028-3908(99)00003-9. PMID 10465684.