PCDH12

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Protocadherin 12
Identifiers
Symbols PCDH12 ; VE-cadherin-2; VECAD2
External IDs OMIM605622 MGI1855700 HomoloGene9574 GeneCards: PCDH12 Gene
RNA expression pattern
PBB GE PCDH12 219656 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51294 53601
Ensembl ENSG00000113555 ENSMUSG00000024440
UniProt Q9NPG4 O55134
RefSeq (mRNA) NM_016580 NM_017378
RefSeq (protein) NP_057664 NP_059074
Location (UCSC) Chr 5:
141.32 – 141.35 Mb
Chr 18:
38.27 – 38.28 Mb
PubMed search [1] [2]

Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.[1][2][3]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no effect on cell migration or growth.[3]

References[edit]

  1. ^ Wu Q, Maniatis T (Apr 2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc Natl Acad Sci U S A 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726. 
  2. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  3. ^ a b "Entrez Gene: PCDH12 protocadherin 12". 

Further reading[edit]