PCDH17

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Protocadherin 17
Identifiers
Symbols PCDH17 ; PCDH68; PCH68
External IDs OMIM611760 MGI2684924 HomoloGene8700 GeneCards: PCDH17 Gene
RNA expression pattern
PBB GE PCDH17 205656 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 27253 219228
Ensembl ENSG00000118946 ENSMUSG00000035566
UniProt O14917 E9PXF0
RefSeq (mRNA) NM_001040429 NM_001013753
RefSeq (protein) NP_001035519 NP_001013775
Location (UCSC) Chr 13:
58.21 – 58.3 Mb
Chr 14:
84.44 – 84.54 Mb
PubMed search [1] [2]

Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.[1][2]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.[2] PCDH17 promoter methylation is found to be closely associated with bladder cancer malignancy [3]

References[edit]

  1. ^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267. 
  2. ^ a b "Entrez Gene: PCDH17 protocadherin 17". 
  3. ^ Wang XB (Apr 2014). "Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma.". J Int Med Res. 42: 292–9. PMID 24567353. 

Further reading[edit]