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Protocadherin 17
Symbols PCDH17 ; PCDH68; PCH68
External IDs OMIM611760 MGI2684924 HomoloGene8700 GeneCards: PCDH17 Gene
RNA expression pattern
PBB GE PCDH17 205656 at tn.png
More reference expression data
Species Human Mouse
Entrez 27253 219228
Ensembl ENSG00000118946 ENSMUSG00000035566
UniProt O14917 E9PXF0
RefSeq (mRNA) NM_001040429 NM_001013753
RefSeq (protein) NP_001035519 NP_001013775
Location (UCSC) Chr 13:
58.21 – 58.3 Mb
Chr 14:
84.44 – 84.54 Mb
PubMed search [1] [2]

Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.[1][2]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.[2] PCDH17 promoter methylation is found to be closely associated with bladder cancer malignancy [3]


  1. ^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267. 
  2. ^ a b "Entrez Gene: PCDH17 protocadherin 17". 
  3. ^ Wang XB (Apr 2014). "Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma.". J Int Med Res. 42: 292–9. doi:10.1177/0300060513504364. PMID 24567353. 

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