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Protocadherin 18
Symbols PCDH18 ; PCDH68L
External IDs OMIM608287 MGI1920423 HomoloGene10389 GeneCards: PCDH18 Gene
RNA expression pattern
PBB GE PCDH18 gnf1h00321 at tn.png
More reference expression data
Species Human Mouse
Entrez 54510 73173
Ensembl ENSG00000189184 ENSMUSG00000037892
UniProt Q9HCL0 Q8VHR0
RefSeq (mRNA) NM_001300828 NM_130448
RefSeq (protein) NP_001287757 NP_569715
Location (UCSC) Chr 4:
138.44 – 138.45 Mb
Chr 3:
49.74 – 49.76 Mb
PubMed search [1] [2]

Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.[1][2][3]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.[3]


  1. ^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267. 
  2. ^ Wolverton T, Lalande M (Sep 2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318. 
  3. ^ a b "Entrez Gene: PCDH18 protocadherin 18". 

Further reading[edit]