PCDH18

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Protocadherin 18
Identifiers
Symbols PCDH18 ; PCDH68L
External IDs OMIM608287 MGI1920423 HomoloGene10389 GeneCards: PCDH18 Gene
RNA expression pattern
PBB GE PCDH18 gnf1h00321 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 54510 73173
Ensembl ENSG00000189184 ENSMUSG00000037892
UniProt Q9HCL0 Q8VHR0
RefSeq (mRNA) NM_001300828 NM_130448
RefSeq (protein) NP_001287757 NP_569715
Location (UCSC) Chr 4:
138.44 – 138.45 Mb
Chr 3:
49.74 – 49.76 Mb
PubMed search [1] [2]

Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.[1][2][3]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.[3]

References[edit]

  1. ^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267. 
  2. ^ Wolverton T, Lalande M (Sep 2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318. 
  3. ^ a b "Entrez Gene: PCDH18 protocadherin 18". 

Further reading[edit]