PCDH8

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Protocadherin 8
Identifiers
Symbols PCDH8 ; ARCADLIN; PAPC
External IDs OMIM603580 MGI1306800 HomoloGene1943 GeneCards: PCDH8 Gene
RNA expression pattern
PBB GE PCDH8 206935 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5100 18530
Ensembl ENSG00000136099 ENSMUSG00000036422
UniProt O95206 Q7TSK3
RefSeq (mRNA) NM_002590 NM_001042726
RefSeq (protein) NP_002581 NP_001036191
Location (UCSC) Chr 13:
53.42 – 53.42 Mb
Chr 14:
79.77 – 79.77 Mb
PubMed search [1] [2]

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.[1][2][3]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.[3]

References[edit]

  1. ^ Strehl S, Glatt K, Liu QM, Glatt H, Lalande M (Dec 1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics 53 (1): 81–9. doi:10.1006/geno.1998.5467. PMID 9787079. 
  2. ^ Strehl S, LaSalle JM, Lalande M (Oct 1997). "High-resolution analysis of DNA replication domain organization across an R/G-band boundary". Mol Cell Biol 17 (10): 6157–66. PMC 232466. PMID 9315676. 
  3. ^ a b "Entrez Gene: PCDH8 protocadherin 8". 

Further reading[edit]