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Protocadherin 8
External IDs OMIM603580 MGI1306800 HomoloGene1943 GeneCards: PCDH8 Gene
RNA expression pattern
PBB GE PCDH8 206935 at tn.png
More reference expression data
Species Human Mouse
Entrez 5100 18530
Ensembl ENSG00000136099 ENSMUSG00000036422
UniProt O95206 Q7TSK3
RefSeq (mRNA) NM_002590 NM_001042726
RefSeq (protein) NP_002581 NP_001036191
Location (UCSC) Chr 13:
53.42 – 53.42 Mb
Chr 14:
79.77 – 79.77 Mb
PubMed search [1] [2]

Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene.[1][2][3]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.[3]


  1. ^ Strehl S, Glatt K, Liu QM, Glatt H, Lalande M (Dec 1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics 53 (1): 81–9. doi:10.1006/geno.1998.5467. PMID 9787079. 
  2. ^ Strehl S, LaSalle JM, Lalande M (Oct 1997). "High-resolution analysis of DNA replication domain organization across an R/G-band boundary". Mol Cell Biol 17 (10): 6157–66. PMC 232466. PMID 9315676. 
  3. ^ a b "Entrez Gene: PCDH8 protocadherin 8". 

Further reading[edit]