This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes an integral membrane protein that is thought to function in cell adhesion in a CNS-specific manner. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons. Notable is the large first exon encoding the extracellular region, including 6 cadherin domains and a transmembrane region. Alternative splicing yields isoforms with unique cytoplasmic tails.
^Strehl S, Glatt K, Liu QM, Glatt H, Lalande M (Dec 1998). "Characterization of two novel protocadherins (PCDH8 and PCDH9) localized on human chromosome 13 and mouse chromosome 14". Genomics53 (1): 81–9. doi:10.1006/geno.1998.5467. PMID9787079.
Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev.14 (10): 1169–80. PMID10817752.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol.299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID10835267.
Yamagata K, Andreasson KI, Sugiura H, et al. (1999). "Arcadlin is a neural activity-regulated cadherin involved in long term potentiation". J. Biol. Chem.274 (27): 19473–1979. doi:10.1074/jbc.274.27.19473. PMID10383464.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID16713569.