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Protocadherin alpha 12
Symbols PCDHA12 ; PCDH-ALPHA12
External IDs OMIM606318 HomoloGene135720 GeneCards: PCDHA12 Gene
Species Human Mouse
Entrez 56137 12943
Ensembl ENSG00000251664 ENSMUSG00000007440
UniProt Q9UN75 O88689
RefSeq (mRNA) NM_018903 NM_009961
RefSeq (protein) NP_061726 NP_034091
Location (UCSC) Chr 5:
140.26 – 140.39 Mb
Chr 18:
36.93 – 37.19 Mb
PubMed search [1] [2]

Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene.[1][2]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[2]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHA12 protocadherin alpha 12". 

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