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Protocadherin alpha 3
Protein PCDHA3 PDB 1wuz.png
PDB rendering based on 1wuz.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606309 MGI2447313 HomoloGene129613 GeneCards: PCDHA3 Gene
RNA expression pattern
PBB GE PCDHA3 210572 at tn.png
PBB GE PCDHA3 211870 s at tn.png
More reference expression data
Species Human Mouse
Entrez 56145 192163
Ensembl ENSG00000255408 ENSMUSG00000091969
UniProt Q9Y5H8 n/a
RefSeq (mRNA) NM_018906 NM_138662
RefSeq (protein) NP_061729 NP_619603
Location (UCSC) Chr 5:
140.18 – 140.39 Mb
Chr 18:
37.11 – 37.11 Mb
PubMed search [1] [2]

Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene.[1][2]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[2]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHA3 protocadherin alpha 3". 

Further reading[edit]