PCDHA4

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Protocadherin alpha 4
Protein PCDHA4 PDB 1wuz.png
PDB rendering based on 1wuz.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PCDHA4 ; CNR1; CNRN1; CRNR1; PCDH-ALPHA4
External IDs OMIM606310 MGI1298406 HomoloGene130626 GeneCards: PCDHA4 Gene
Orthologs
Species Human Mouse
Entrez 56144 12936
Ensembl ENSG00000204967 ENSMUSG00000007440
UniProt Q9UN74 O88689
RefSeq (mRNA) NM_018907 NM_007766
RefSeq (protein) NP_061730 NP_031792
Location (UCSC) Chr 5:
140.19 – 140.39 Mb
Chr 18:
36.93 – 37.19 Mb
PubMed search [1] [2]

Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene.[1][2][3]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[3]

References[edit]

  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T (Apr 2000). "Genomic organization of the family of CNR cadherin genes in mice and humans". Genomics 63 (1): 75–87. doi:10.1006/geno.1999.6066. PMID 10662547. 
  3. ^ a b "Entrez Gene: PCDHA4 protocadherin alpha 4". 

Further reading[edit]