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Protocadherin alpha 5
Protein PCDHA5 PDB 1wuz.png
PDB rendering based on 1wuz.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606311 MGI1298371 HomoloGene49565 GeneCards: PCDHA5 Gene
RNA expression pattern
PBB GE PCDHA5 211838 x at tn.png
More reference expression data
Species Human Mouse
Entrez 56143 12941
Ensembl ENSG00000204965 n/a
UniProt Q9Y5H7 Q91Y15
RefSeq (mRNA) NM_018908 NM_009959
RefSeq (protein) NP_061731 NP_034089
Location (UCSC) Chr 5:
140.2 – 140.39 Mb
PubMed search [1] [2]

Protocadherin alpha-5 is a protein that in humans is encoded by the PCDHA5 gene.[1][2][3]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[3]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T (Apr 2000). "Genomic organization of the family of CNR cadherin genes in mice and humans". Genomics 63 (1): 75–87. doi:10.1006/geno.1999.6066. PMID 10662547. 
  3. ^ a b "Entrez Gene: PCDHA5 protocadherin alpha 5". 

Further reading[edit]