From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protocadherin alpha 6
Protein PCDHA6 PDB 1wuz.png
PDB rendering based on 1wuz.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606312 MGI1298367 HomoloGene75098 GeneCards: PCDHA6 Gene
RNA expression pattern
PBB GE PCDHA6 211811 s at tn.png
More reference expression data
Species Human Mouse
Entrez 56142 12937
Ensembl ENSG00000081842 ENSMUSG00000079714
UniProt Q9UN73 n/a
RefSeq (mRNA) NM_018909 NM_007767
RefSeq (protein) NP_061732 NP_031793
Location (UCSC) Chr 5:
140.21 – 140.39 Mb
Chr 18:
37.13 – 37.35 Mb
PubMed search [1] [2]

Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene.[1][2][3]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[3]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T (Apr 2000). "Genomic organization of the family of CNR cadherin genes in mice and humans". Genomics 63 (1): 75–87. doi:10.1006/geno.1999.6066. PMID 10662547. 
  3. ^ a b "Entrez Gene: PCDHA6 protocadherin alpha 6". 

Further reading[edit]