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Protocadherin alpha 9
External IDs OMIM606315 MGI2681879 HomoloGene129614 GeneCards: PCDHA9 Gene
RNA expression pattern
PBB GE PCDHA9 208205 at tn.png
More reference expression data
Species Human Mouse
Entrez 9752 353235
Ensembl ENSG00000204961 n/a
UniProt Q9Y5H5 n/a
RefSeq (mRNA) NM_014005 NM_201243
RefSeq (protein) NP_054724 NP_957695
Location (UCSC) Chr 5:
140.23 – 140.39 Mb
PubMed search [1] [2]

Protocadherin alpha-9 is a protein that in humans is encoded by the PCDHA9 gene.[1][2]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome 5 that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences.

The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[2]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHA9 protocadherin alpha 9". 

Further reading[edit]