PCDHB10

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Protocadherin beta 10
Identifiers
Symbols PCDHB10 ; PCDH-BETA10; PCHB10
External IDs OMIM606336 MGI2136756 HomoloGene56829 GeneCards: PCDHB10 Gene
Orthologs
Species Human Mouse
Entrez 56126 93889
Ensembl ENSG00000120324 ENSMUSG00000048347
UniProt Q9UN67 E9PXJ6
RefSeq (mRNA) NM_018930 NM_053143
RefSeq (protein) NP_061753 NP_444373
Location (UCSC) Chr 5:
140.57 – 140.58 Mb
Chr 18:
37.49 – 37.49 Mb
PubMed search [1] [2]

Protocadherin beta-10 is a protein that in humans is encoded by the PCDHB10 gene.[1][2]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[2]

References[edit]

  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB10 protocadherin beta 10". 

Further reading[edit]