PCDHB11

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Protocadherin beta 11
Identifiers
Symbols PCDHB11 ; ME2; PCDH-BETA11
External IDs OMIM606337 MGI2136757 HomoloGene134302 GeneCards: PCDHB11 Gene
RNA expression pattern
PBB GE PCDHB11 208504 x at tn.png
PBB GE PCDHB3 221408 x at tn.png
PBB GE PCDHB11 221450 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 56125 93892
Ensembl ENSG00000197479 ENSMUSG00000044022
UniProt Q9Y5F2 Q91V48
RefSeq (mRNA) NM_018931 NM_053146
RefSeq (protein) NP_061754 NP_444376
Location (UCSC) Chr 5:
140.58 – 140.58 Mb
Chr 18:
37.51 – 37.52 Mb
PubMed search [1] [2]

Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.[1][2]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[2]

References[edit]

  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB11 protocadherin beta 11". 

Further reading[edit]