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Protocadherin beta 12
Symbols PCDHB12 ; PCDH-BETA12
External IDs OMIM606338 HomoloGene128411 GeneCards: PCDHB12 Gene
RNA expression pattern
PBB GE PCDHB11 208504 x at tn.png
PBB GE PCDHB3 221408 x at tn.png
PBB GE PCDHB12 221450 x at tn.png
More reference expression data
Species Human Mouse
Entrez 56124 93890
Ensembl ENSG00000120328 ENSMUSG00000043313
UniProt Q9Y5F1 Q91Y01
RefSeq (mRNA) NM_018932 NM_053144
RefSeq (protein) NP_061755 NP_444374
Location (UCSC) Chr 5:
140.59 – 140.59 Mb
Chr 18:
37.5 – 37.5 Mb
PubMed search [1] [2]

Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene.[1][2]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[2]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB12 protocadherin beta 12". 

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