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Protocadherin beta 14
Symbols PCDHB14 ; PCDH-BETA14
External IDs OMIM606340 MGI2136758 HomoloGene69264 GeneCards: PCDHB14 Gene
RNA expression pattern
PBB GE PCDHB3 221408 x at tn.png
PBB GE PCDHB14 221410 x at tn.png
PBB GE PCDHB14 221450 x at tn.png
More reference expression data
Species Human Mouse
Entrez 56122 93891
Ensembl ENSG00000120327 ENSMUSG00000046191
UniProt Q9Y5E9 n/a
RefSeq (mRNA) NM_018934 NM_053145
RefSeq (protein) NP_061757 NP_444375
Location (UCSC) Chr 5:
140.6 – 140.61 Mb
Chr 18:
37.5 – 37.51 Mb
PubMed search [1] [2]

Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene.[1][2]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[2]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB14 protocadherin beta 14". 

Further reading[edit]