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Protocadherin beta 2
External IDs OMIM606328 MGI2136735 HomoloGene69266 GeneCards: PCDHB2 Gene
RNA expression pattern
PBB GE PCDHB2 221410 x at tn.png
PBB GE PCDHB2 221450 x at tn.png
More reference expression data
Species Human Mouse
Entrez 56133 93873
Ensembl ENSG00000112852 ENSMUSG00000051599
UniProt Q9Y5E7 Q91Y00
RefSeq (mRNA) NM_018936 NM_053127
RefSeq (protein) NP_061759 NP_444357
Location (UCSC) Chr 5:
140.47 – 140.48 Mb
Chr 18:
37.29 – 37.3 Mb
PubMed search [1] [2]

Protocadherin beta-2 is a protein that in humans is encoded by the PCDHB2 gene.[1][2]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[2]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–790. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB2 protocadherin beta 2". 

Further reading[edit]