PCDHB5

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Protocadherin beta 5
Identifiers
Symbols PCDHB5 ; PCDH-BETA5
External IDs OMIM606331 MGI2136745 HomoloGene88834 GeneCards: PCDHB5 Gene
RNA expression pattern
PBB GE PCDHB3 221408 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 26167 93881
Ensembl ENSG00000113209 ENSMUSG00000045657
UniProt Q9Y5E4 A4QMV0
RefSeq (mRNA) NM_015669 NM_053135
RefSeq (protein) NP_056484 NP_444365
Location (UCSC) Chr 5:
140.51 – 140.52 Mb
Chr 18:
37.41 – 37.41 Mb
PubMed search [1] [2]

Protocadherin beta-5 is a protein that in humans is encoded by the PCDHB5 gene.[1][2]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[2]

References[edit]

  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB5 protocadherin beta 5". 

Further reading[edit]