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Protocadherin beta 7
External IDs OMIM606333 MGI2136750 HomoloGene32429 GeneCards: PCDHB7 Gene
RNA expression pattern
PBB GE PCDHB3 221408 x at tn.png
PBB GE PCDHB12 221450 x at tn.png
More reference expression data
Species Human Mouse
Entrez 56129 93886
Ensembl ENSG00000113212 ENSMUSG00000047033
UniProt Q9Y5E2 Q91Y04
RefSeq (mRNA) NM_018940 NM_053140
RefSeq (protein) NP_061763 NP_444370
Location (UCSC) Chr 5:
140.55 – 140.56 Mb
Chr 18:
37.47 – 37.48 Mb
PubMed search [1] [2]

Protocadherin beta-7 is a protein that in humans is encoded by the PCDHB7 gene.[1][2]

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. The transcript for this particular family member uses more than one polyadenylation site.[2]


  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHB7 protocadherin beta 7". 

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