PCDHGA12

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Protocadherin gamma subfamily A, 12
Identifiers
Symbols PCDHGA12 ; CDH21; FIB3; PCDH-GAMMA-A12
External IDs OMIM603059 MGI1935229 HomoloGene134588 GeneCards: PCDHGA12 Gene
Orthologs
Species Human Mouse
Entrez 26025 93724
Ensembl ENSG00000253159 ENSMUSG00000023036
UniProt O60330 Q91XY7
RefSeq (mRNA) NM_003735 NM_033595
RefSeq (protein) NP_003726 NP_291073
Location (UCSC) Chr 5:
140.81 – 140.89 Mb
Chr 18:
37.67 – 37.84 Mb
PubMed search [1] [2]

Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene.[1][2]

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.[2]

References[edit]

  1. ^ Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. 
  2. ^ a b "Entrez Gene: PCDHGA12 protocadherin gamma subfamily A, 12". 

Further reading[edit]