Polycomb group RING finger protein 2 is a protein that in humans is encoded by the PCGF2gene.
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
^Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M (Aug 1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif". Gene129 (2): 249–255. doi:10.1016/0378-1119(93)90275-8. PMID8325509.
Kimura M; Koseki Y; Yamashita M et al. (2001). "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene". Immunity15 (2): 275–287. doi:10.1016/S1074-7613(01)00182-0. PMID11520462.Cite uses deprecated parameter |author-separator= (help)
Miyazaki K; Inoue H; Onai N et al. (2002). "Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18". Immunol. Lett.80 (2): 139–143. doi:10.1016/S0165-2478(01)00315-7. PMID11750047.Cite uses deprecated parameter |author-separator= (help)
Suzuki M; Mizutani-Koseki Y; Fujimura Y et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development129 (18): 4171–83. PMID12183370.Cite uses deprecated parameter |author-separator= (help)
Matsuo F; Yano K; Saito H et al. (2002). "Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines". Breast Cancer9 (1): 33–38. doi:10.1007/BF02967544. PMID12196719.Cite uses deprecated parameter |author-separator= (help)
Silva J; García JM; Peña C et al. (2007). "Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas". Clin. Cancer Res.12 (23): 6929–6936. doi:10.1158/1078-0432.CCR-06-0788. PMID17145810.Cite uses deprecated parameter |author-separator= (help)