PCGF2

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Polycomb group ring finger 2
Protein PCGF2 PDB 2h0d.png
PDB rendering based on 2h0d.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PCGF2 ; MEL-18; RNF110; ZNF144
External IDs OMIM600346 MGI99161 HomoloGene5174 GeneCards: PCGF2 Gene
RNA expression pattern
PBB GE PCGF2 213551 x at tn.png
PBB GE PCGF2 203792 x at tn.png
PBB GE PCGF2 203793 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7703 22658
Ensembl ENSG00000056661 ENSMUSG00000018537
UniProt P35227 P23798
RefSeq (mRNA) NM_007144 NM_001163307
RefSeq (protein) NP_009075 NP_001156779
Location (UCSC) Chr 17:
36.89 – 36.91 Mb
Chr 11:
97.69 – 97.7 Mb
PubMed search [1] [2]

Polycomb group RING finger protein 2 is a protein that in humans is encoded by the PCGF2 gene.[1][2]

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.[2]

References[edit]

  1. ^ Ishida A, Asano H, Hasegawa M, Koseki H, Ono T, Yoshida MC, Taniguchi M, Kanno M (Aug 1993). "Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif". Gene 129 (2): 249–255. doi:10.1016/0378-1119(93)90275-8. PMID 8325509. 
  2. ^ a b "Entrez Gene: PCGF2 polycomb group ring finger 2". 

Further reading[edit]