PCK1

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Phosphoenolpyruvate carboxykinase 1 (soluble)
Protein PCK1 PDB 1khb.png
PDB rendering based on 1khb.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PCK1 ; PEPCK-C; PEPCK1; PEPCKC
External IDs OMIM614168 MGI97501 HomoloGene1944 ChEMBL: 2911 GeneCards: PCK1 Gene
EC number 4.1.1.32
RNA expression pattern
PBB GE PCK1 208383 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5105 18534
Ensembl ENSG00000124253 ENSMUSG00000027513
UniProt P35558 Q9Z2V4
RefSeq (mRNA) NM_002591 NM_011044
RefSeq (protein) NP_002582 NP_035174
Location (UCSC) Chr 20:
56.14 – 56.14 Mb
Chr 2:
173.15 – 173.16 Mb
PubMed search [1] [2]

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an enzyme which in humans is encoded by the PCK1 gene.[1][2]

Function[edit]

This enzyme is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.[1]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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GlycolysisGluconeogenesis_WP534 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to Entrez go to article go to article go to article go to article go to article go to WikiPathways go to article go to Entrez go to article
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Glycolysis and Gluconeogenesis edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534". 

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)". 
  2. ^ Pilz AJ, Willer E, Povey S, Abbott CM (October 1992). "The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2". Ann. Hum. Genet. 56 (Pt 4): 289–93. doi:10.1111/j.1469-1809.1992.tb01155.x. PMID 1492743. 

Further reading[edit]