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Cadherin-related family member 2
Symbols CDHR2 ; PCDH24; PCLKC
External IDs MGI2687323 HomoloGene134510 GeneCards: CDHR2 Gene
RNA expression pattern
PBB GE PCLKC 220186 s at tn.png
More reference expression data
Species Human Mouse
Entrez 54825 268663
Ensembl ENSG00000074276 ENSMUSG00000034918
UniProt Q9BYE9 B9EJ32
RefSeq (mRNA) NM_001171976 NM_001033364
RefSeq (protein) NP_001165447 NP_001028536
Location (UCSC) Chr 5:
175.97 – 176.02 Mb
Chr 13:
54.7 – 54.74 Mb
PubMed search [1] [2]

Protocadherin-24 is a protein that in humans is encoded by the PCDH24 gene.[1][2][3]

This gene is a member of the protocadherin family, which represents a subset of the larger cadherin superfamily. The members of the protocadherin family encode non-classical cadherins that function as calcium-dependent cell-cell adhesion molecules. The kidney-expressed gene product has a signal peptide, nine cadherin repeat domains and a unique cytoplasmic region. This protocadherin represents a new candidate for tumor suppression.[3]


PCLKC has been shown to interact with MAST2.[2]


  1. ^ Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270. 
  2. ^ a b Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771. 
  3. ^ a b "Entrez Gene: PCLKC protocadherin LKC". 

Further reading[edit]