Chloroxylenol
| Chloroxylenol | |
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4-Chloro-3,5-dimethylphenol[1] |
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| Identifiers | |
| CAS number | 88-04-0  |
| PubChem | 2723 |
| ChemSpider | 21106017 |
| UNII | 0F32U78V2Q |
| EC number | 201-793-8 |
| KEGG | D03473 |
| MeSH | chloroxylenol |
| ChEMBL | CHEMBL398440  |
| RTECS number | ZE6850000 |
| ATC code | D08 |
| Beilstein Reference | 1862539 |
| Jmol-3D images | Image 1 Image 2 |
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| Properties | |
| Molecular formula | C8H9ClO |
| Molar mass | 156.61 g mol−1 |
| Exact mass | 156.034192617 g mol-1 |
| Melting point |
114-116 °C, 387-389 K, 237-241 °F |
| log P | 3.377 |
| Acidity (pKa) | 9.76 |
| Basicity (pKb) | 4.24 |
| Hazards | |
| GHS pictograms |  |
| GHS signal word | WARNING |
| GHS hazard statements | H302, H315, H317, H319 |
| GHS precautionary statements | P280, P305+351+338 |
| EU Index | 604-038-00-4 |
| EU classification |  Xn |
| R-phrases | R22, R36/38, R43 |
| S-phrases | (S2), S24, S37 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | |
| Infobox references | |
Chloroxylenol (4-chloro-3,5-dimethylphenol) is an antimicrobial chemical compound used to control bacteria, algae, and fungi in adhesives, emulsions, paints, and wash tanks.[2] It is also commonly used in antibacterial soaps such as Dettol and ointments, such as the now discontinued Medicated Vaseline.[3] Studies have shown a low anti microbial activity which is enhanced by additives. Its antibacterial action is due to disruption of cell membrane potentials.[4]
Chloroxylenol is not significantly toxic to humans and other mammals, is practically non-toxic to birds, moderately toxic to freshwater invertebrates and highly toxic to fish.[2] It is a mild skin irritant and may trigger allergic reactions in some individuals. Cross sensitivity with chlorocresol is common.[3]
[edit] References
- ^ "chloroxylenol - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification and Related Records. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2723&loc=ec_rcs. Retrieved 7 October 2011.
- ^ a b http://www.epa.gov/oppsrrd1/REDs/factsheets/3045fact.pdf
- ^ a b Ascenzi, Joseph M. (1996). "Chloroxylenol: an old-new antimicrobial". Handbook of disinfectants and antiseptics. New York: M. Dekker. ISBN 9780824795245. http://books.google.com/?id=tFPW4D70BmgC&pg=PA265.
- ^ Aly, R; Malbach, H (1988). "Comparative antibacterial efficacy of a 2-minute surgical scrub with chlorhexidine gluconate, povidone-iodine, and chloroxylenol sponge-brushes". American Journal of Infection Control 16 (4): 173–7. doi:10.1016/0196-6553(88)90029-6. PMID 3189943.
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