PCNT

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Pericentrin
Identifiers
Symbols PCNT ; KEN; MOPD2; PCN; PCNT2; PCNTB; PCTN2; SCKL4
External IDs OMIM605925 MGI102722 HomoloGene86942 GeneCards: PCNT Gene
RNA expression pattern
PBB GE PCNT 203660 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5116 18541
Ensembl ENSG00000160299 ENSMUSG00000001151
UniProt O95613 P48725
RefSeq (mRNA) NM_006031 NM_008787
RefSeq (protein) NP_006022 NP_032813
Location (UCSC) Chr 21:
47.74 – 47.87 Mb
Chr 10:
76.35 – 76.44 Mb
PubMed search [1] [2]

Pericentrin (kendrin), also known as PCNT, is a protein which in humans is encoded by the PCNT gene.[1][2][3]

Function[edit]

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus.[4] The protein interacts with the microtubule nucleation component γ-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell cycle progression.[1]

Interactions[edit]

PCNT has been shown to interact with PCM1.[5]

References[edit]

  1. ^ a b "Entrez Gene: PCNT pericentrin (kendrin)". 
  2. ^ Chen H, Gos A, Morris MA, Antonarakis SE (August 1996). "Localization of a human homolog of the mouse pericentrin gene (PCNT) to chromosome 21qter". Genomics 35 (3): 620–4. doi:10.1006/geno.1996.0411. PMID 8812505. 
  3. ^ Flory MR, Moser MJ, Monnat RJ, Davis TN (May 2000). "Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin". Proceedings of the National Academy of Sciences of the United States of America 97 (11): 5919–23. doi:10.1073/pnas.97.11.5919. PMC 18534. PMID 10823944. 
  4. ^ Gillingham, A.; Munro, S. (2000). "The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin". EMBO Reports 1 (6): 524–529. doi:10.1093/embo-reports/kvd105. PMC 1083777. PMID 11263498.  edit
  5. ^ Li, Q; Hansen D; Killilea A; Joshi H C; Palazzo R E; Balczon R (Feb 2001). "Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1". J. Cell. Sci. (England) 114 (Pt 4): 797–809. ISSN 0021-9533. PMID 11171385. 

Further reading[edit]