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Cyclin-dependent kinase 16
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM311550 MGI97516 HomoloGene7878 ChEMBL: 4597 GeneCards: CDK16 Gene
EC number
RNA expression pattern
PBB GE PCTK1 207239 s at tn.png
PBB GE PCTK1 208823 s at tn.png
PBB GE PCTK1 208824 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5127 18555
Ensembl ENSG00000102225 ENSMUSG00000031065
UniProt Q00536 Q04735
RefSeq (mRNA) NM_001170460 NM_011049
RefSeq (protein) NP_001163931 NP_035179
Location (UCSC) Chr X:
47.08 – 47.09 Mb
Chr X:
20.69 – 20.7 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the PCTK1 gene.[1][2]

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.[2]


PCTK1 has been shown to interact with CDK5R1.[3]


  1. ^ Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene 7 (11): 2249–58. PMID 1437147. 
  2. ^ a b "Entrez Gene: PCTK1 PCTAIRE protein kinase 1". 
  3. ^ Cheng, Kai; Li Zhen, Fu Wing-Yu, Wang Jerry H, Fu Amy K Y, Ip Nancy Y (Aug 2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. (United States) 277 (35): 31988–93. doi:10.1074/jbc.M201161200. ISSN 0021-9258. PMID 12084709. 

Further reading[edit]