PCTK1

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Cyclin-dependent kinase 16
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CDK16 ; PCTAIRE; PCTAIRE1; PCTGAIRE; PCTK1
External IDs OMIM311550 MGI97516 HomoloGene7878 ChEMBL: 4597 GeneCards: CDK16 Gene
EC number 2.7.11.22
RNA expression pattern
PBB GE PCTK1 207239 s at tn.png
PBB GE PCTK1 208823 s at tn.png
PBB GE PCTK1 208824 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5127 18555
Ensembl ENSG00000102225 ENSMUSG00000031065
UniProt Q00536 Q04735
RefSeq (mRNA) NM_001170460 NM_011049
RefSeq (protein) NP_001163931 NP_035179
Location (UCSC) Chr HG29_PATCH:
47.08 – 47.09 Mb
Chr X:
20.69 – 20.7 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the PCTK1 gene.[1][2]

Function[edit]

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.[2]

Interactions[edit]

PCTK1 has been shown to interact with CDK5R1.[3]

References[edit]

  1. ^ Okuda T, Cleveland JL, Downing JR (Dec 1992). "PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family". Oncogene 7 (11): 2249–58. PMID 1437147. 
  2. ^ a b "Entrez Gene: PCTK1 PCTAIRE protein kinase 1". 
  3. ^ Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (Aug 2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi:10.1074/jbc.M201161200. PMID 12084709. 

Further reading[edit]

  • Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C et al. (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. PMC 556772. PMID 1639063. 
  • Knight JC, Renwick PJ, Downing JR, Okuda T (1995). "Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3". Cytogenet. Cell Genet. 71 (2): 155–7. doi:10.1159/000134097. PMID 7656587. 
  • Okuda T, Valentine VA, Shapiro DN, Downing JR (1994). "Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes". Genomics 21 (1): 217–21. doi:10.1006/geno.1994.1245. PMID 8088790. 
  • Carrel L, Clemson CM, Dunn JM, Miller AP, Hunt PA, Lawrence JB et al. (1996). "X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse". Hum. Mol. Genet. 5 (3): 391–401. doi:10.1093/hmg/5.3.391. PMID 8852665. 
  • Sladeczek F, Camonis JH, Burnol AF, Le Bouffant F (1997). "The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins". Mol. Gen. Genet. 254 (5): 571–7. doi:10.1007/s004380050453. PMID 9197417. 
  • Esposito T, Gianfrancesco F, Ciccodicola A, D'Esposito M, Nagaraja R, Mazzarella R et al. (1997). "Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E". Genomics 43 (2): 183–90. doi:10.1006/geno.1997.4797. PMID 9244435. 
  • Yu X, Wu LC, Bowcock AM, Aronheim A, Baer R (1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression". J. Biol. Chem. 273 (39): 25388–92. doi:10.1074/jbc.273.39.25388. PMID 9738006. 
  • Le Bouffant F, Capdevielle J, Guillemot JC, Sladeczek F (1998). "Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins". Eur. J. Biochem. 257 (1): 112–20. doi:10.1046/j.1432-1327.1998.2570112.x. PMID 9799109. 
  • Besset V, Rhee K, Wolgemuth DJ (1999). "The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation". Cell Growth Differ. 10 (3): 173–81. PMID 10099831. 
  • Cheng K, Li Z, Fu WY, Wang JH, Fu AK, Ip NY (2002). "Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35". J. Biol. Chem. 277 (35): 31988–93. doi:10.1074/jbc.M201161200. PMID 12084709. 
  • Graeser R, Gannon J, Poon RY, Dubois T, Aitken A, Hunt T (2002). "Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells". J. Cell. Sci. 115 (Pt 17): 3479–90. PMID 12154078. 
  • Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A et al. (2004). "Protein profile of tax-associated complexes". J. Biol. Chem. 279 (1): 495–508. doi:10.1074/jbc.M310069200. PMID 14530271. 
  • Palmer KJ, Konkel JE, Stephens DJ (2005). "PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport". J. Cell. Sci. 118 (Pt 17): 3839–47. doi:10.1242/jcs.02496. PMID 16091426. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Liu Y, Cheng K, Gong K, Fu AK, Ip NY (2006). "Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis". J. Biol. Chem. 281 (15): 9852–8. doi:10.1074/jbc.M513496200. PMID 16461345.