From Wikipedia, the free encyclopedia
Jump to: navigation, search
Phosphodiesterase 11A
Symbols PDE11A ; PPNAD2
External IDs OMIM604961 MGI3036251 HomoloGene56763 IUPHAR: 1311 ChEMBL: 2717 GeneCards: PDE11A Gene
EC number,
RNA expression pattern
PBB GE PDE11A 221110 x at tn.png
More reference expression data
Species Human Mouse
Entrez 50940 241489
Ensembl ENSG00000128655 ENSMUSG00000075270
UniProt Q9HCR9 P0C1Q2
RefSeq (mRNA) NM_001077196 NM_001081033
RefSeq (protein) NP_001070664 NP_001074502
Location (UCSC) Chr 2:
178.49 – 178.97 Mb
Chr 2:
75.99 – 76.34 Mb
PubMed search [1] [2]

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.[1][2]

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.[2]



  1. ^ Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303. PMID 10725373. 
  2. ^ a b "Entrez Gene: PDE11A phosphodiesterase 11A". 
  3. ^ Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi:10.1016/j.chembiol.2011.12.010. PMID 22284362. 

Further reading[edit]