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Phosphodiesterase 4C, cAMP-specific
Protein PDE4C PDB 1LXU.png
Rendering based on PDB 1LXU.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PDE4C ; DPDE1
External IDs OMIM600128 MGI99556 HomoloGene20256 IUPHAR: 1302 ChEMBL: 291 GeneCards: PDE4C Gene
EC number
RNA expression pattern
PBB GE PDE4C 206791 s at tn.png
PBB GE PDE4C 206792 x at tn.png
PBB GE PDE4C 211818 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5143 110385
Ensembl ENSG00000105650 ENSMUSG00000031842
UniProt Q08493 Q3UEI1
RefSeq (mRNA) NM_000923 NM_201607
RefSeq (protein) NP_000914 NP_963901
Location (UCSC) Chr 19:
18.32 – 18.37 Mb
Chr 8:
70.72 – 70.75 Mb
PubMed search [1] [2]

cAMP-specific 3',5'-cyclic phosphodiesterase 4C is an enzyme that in humans is encoded by the PDE4C gene.[1]

Tissue localisation[edit]

PDE4C is predominantly found in peripheral tissues.[2]


  1. ^ "Entrez Gene: PDE4C phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)". 
  2. ^ Zhang, HT (2009). "Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs". Current Pharmaceutical Design 15 (14): 1688–1698. doi:10.2174/138161209788168092. PMID 19442182. 

Further reading[edit]